Covid-19 reinfection: Hong Kong scientists report to start with scenario, but far more research is desired

Covid-19 reinfection: Hong Kong researchers report first case, but more study is needed

He experienced indicators the initially time all over, but no obvious signs the second time, the staff at the University of Hong Kong claimed Monday.

The pre-print examine — which the University of Hong Kong mentioned has been recognized for publication in the journal Medical Infectious Health conditions — discovered that the man’s next circumstance of Covid-19 transpired 142 times right after the initially.

Throughout his to start with episode of disease, the affected person experienced a cough, sore throat, fever and headache for 3 times, according to the review. He analyzed constructive for Covid-19 on March 26.

Then for the duration of his 2nd episode, the individual was returning to Hong Kong from touring in Spain by way of the United Kingdom, and he tested constructive during his entry screening at the Hong Kong airport on August 15, the researchers reported. The male was hospitalized once more but remained asymptomatic.

“The patient obtained re-contaminated 4.5 months soon after the first infection. For that reason, it demonstrates that for this patient, the immunity induced by the initial infection is small long lasting,” Dr. Kelvin Kai-Wang To of the College of Hong Kong, who labored on the review, stated in an e mail to CNN.

For the review, scientists at the university and many hospitals in Hong Kong analyzed specimens gathered from the affected individual 10 times immediately after his indicators emerged in the 1st episode and then a person working day after hospitalization for the 2nd episode.

Genetic analysis proposed that the initial infection was from a strain of the coronavirus most intently similar to strains from the United States or England, and the next infection was most carefully relevant to strains from Switzerland and England.

Coronavirus patient tests positive for a second time but that doesn't mean she was reinfected, expert cautions

“This case illustrates that re-an infection can arise even just just after a number of months of recovery from the to start with infection. Our findings propose that SARS-CoV-2 may persist in people, as is the situation for other widespread-chilly associated human coronaviruses, even if patients have obtained immunity via normal an infection or through vaccination,” the researchers wrote.

The findings also present that men and women who have experienced coronavirus presently should really nevertheless get vaccinated if and when a vaccine results in being obtainable, the researchers wrote.

. “Individuals with earlier COVID-19 infection really should also comply with epidemiological regulate steps these kinds of as universal masking and social distancing,” they wrote.

The researchers called this the “to start with case” of re-infection of Covid-19 in their paper, but other experts are calling for more research.
Recovered coronavirus patients are testing positive again. Can you get reinfected?
“What I assume is definitely important is that we put this into context,” Maria Van Kerkhove, the Globe Health and fitness Organization’s technical direct for coronavirus reaction and head of the emerging conditions and zoonoses device, explained in the course of a media briefing in Geneva on Monday.

“You can find been more than 24 million instances noted to date. And we want to appear at anything like this on a inhabitants level. And so it is really pretty critical that we document this — and that, in nations that can do this, if sequencing can be completed, that would be extremely, incredibly valuable. But we require to not jump to any conclusions,” Van Kerkhove said.

“Even if this is the initially documented case of reinfection, it is probable of course simply because with our working experience with other human coronaviruses, and the MERS coronavirus and the SARS-CoV-1 coronavirus, we know that people today have an antibody reaction for some time but it might wane.”

Covid-19 immunity from antibodies may last only months, UK study suggests

This circumstance of achievable Covid-19 reinfection arrived as no shock to Dr. Paul Hunter, a professor in drugs at the University of East Anglia’s Norwich College of Medicine in Britain who was not involved in the new analyze.

“The report from Hong Kong of a re-infection in a male by COVID-19 that was genetically unique from the very first infection should not be way too surprising. It is, having said that, significant that this is documented,” Hunter claimed in a written assertion distributed by the United kingdom-based Science Media Centre on Monday.

“Of individual notice was that the situation was a youthful and if not healthy person and that the next an infection was diagnosed 4.5 months immediately after the original episode,” he said.

“Commentators have been saying for some time that immunity is not likely to be permanent and might only previous a several months. Specified the diverse intensity of the antibody response in individuals with mild or significant sickness and the subsequent decay in stages, it is very likely that all those with a gentle health issues will have a shorter duration of immunity than these with intense illness.”

Dr. Paul Offit, director of the Vaccine Instruction Centre and professor of pediatrics at Kid’s Healthcare facility of Philadephia, said it was “great news” that the man in the new review had no signs and symptoms the 2nd time he was infected.

“That is all you want to see,” reported Offit, who was not included in the analyze.

He told CNN that this is a excellent indicator that a Covid-19 vaccine will do a little something equivalent.

“It’s encouraging for the vaccine that his initial infection induced an immune reaction that shielded from illness,” Offit reported.

In general, the new analyze “is a textbook instance of how immunity should really get the job done,” Akiko Iwasaki, of the Yale College of Drugs, who was not associated in the review, wrote in a Twitter put up on Monday.

“2nd an infection was asymptomatic. While immunity was not ample to block reinfection, it shielded the person from sickness,” Iwasaki tweeted. “Client experienced no detectable antibody at the time of reinfection but formulated detectable antibody soon after reinfection. This is encouraging.”

She included that because reinfection can arise, herd immunity by natural an infection is unlikely to get rid of the novel coronavirus.

“The only safe and effective way to achieve herd immunity is through vaccination,” Iwasaki tweeted. “Last of all, although this is a fantastic illustration of how key infection can stop sickness from subsequent infection, extra studies are desired to comprehend the assortment of results from reinfection.”

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